Rule 1301:18-6-07 | Non-Marijuana Ingredients.
(A) In accordance with division (A)(17) of section 3796.03 of the Revised Code, each processor shall establish, maintain, and comply with written policies and procedures to ensure all non-marijuana ingredients conform with all standards outlined in this rule.
(B) Notwithstanding any other provision, the division of cannabis control may revoke, amend the permissible scope, or prohibit a non-marijuana ingredient, if the division determines there is reasonable probability that the ingredient, exposure, or use thereof fails to comply with any requirement outlined under this rule or any directive, guidance, standard, or mandate as established by the division.
(C) Each processor shall only utilize non-marijuana ingredients that:
(1) Are obtained from a licensed and regulated source that complies with all applicable requirements of federal and state laws and regulations;
(2) Except for hemp or botanically derived terpenes, for cannabis products that are intended for ingestion, the non-marijuana ingredient must be generally recognized as safe (GRAS) as defined by 21 CFR 170.30(c) and 170.3(f);
(3) Comply with all requirements outlined under this rule;
(4) Comply with all requirements of Chapter 3796. of the Revised Code, and division 1301:18 of the Administrative Code; and
(5) Comply with any other requirement the division deems necessary.
(D) Each processor shall not utilize any non-marijuana ingredients that are:
(1) Toxic or unsafe for human consumption or constitutes a risk to public health or safety;
(2) Prepared or stored in a private residence; or
(3) In violation of any other requirement established by the division.
(E) Each processor shall not utilize any non-marijuana ingredient that would, or is advertised or marketed to, increase potency, toxicity, or addictive potential, would create an unsafe combination with another, intoxicating, psychoactive, or similar substances, including the following:
(1) Nicotine;
(2) Melatonin;
(3) As defined by Chapter 4303. of the Revised Code, any beer, wine, or intoxicating liquor;
(4) As defined by section 201 of 21 USC 321, a dietary supplement, including functional mushrooms and multivitamins;
(5) As defined by section 201 of 21 USC 321, dietary ingredients, including vitamins;
(6) Caffeine, unless all of the following occur:
(a) The licensee submits a request pursuant to rule 1301:18-4-09 of the Administrative Code, which is approved by the division;
(b) The caffeine is naturally occurring in the proposed ingredient; and
(c) The caffeine is ancillary to the ingredient and is not intended to impart a functional effect upon the final form cannabis product.
(7) Polyethylene glycol, unless solely intended for use in one of the following:
(a) Salves, balms, lotions, or other similar cosmetic products; or
(b) Suppositories;
(8) In addition to the prohibitions above, the following ingredients shall not be utilized in the production or manufacture of any cannabis intended for smoking, combustion, or vaporization:
(a) Triglycerides, including medium-chain triglyceride (MCT) oil;
(b) Squalene;
(c) Squalane;
(d) Vitamin E acetate;
(e) Propylene glycol.
(F) In accordance with rule 1301:18-4-09 of the Administrative Code, prior to utilizing any non-marijuana ingredient, each processor shall submit a request to the division.
(1) A processor shall not utilize any non-marijuana ingredient unless and until it receives written approval by the division to proceed; and
(2) A processor shall utilize all non-marijuana ingredients solely in accordance with any limitations, amendments, modifications, or remediations, as required by the division.
(G) Upon receipt of a non-marijuana ingredient at the licensed premises, the processor shall ensure that the outermost package contains sufficient labeling to identify the ingredient and its source.
If the ingredient arrives in packaging that does not contain the required information, the processor shall affix a label with all of the following:
(1) The name of the ingredient;
(2) The name of the originating entity or manufacturer of the ingredient;
(3) The date the processor received the ingredient; and
(4) Any allergen information associated with the ingredient, if applicable.
(H) In the event a processor determines after receipt of a non-marijuana ingredient it fails to meet any mandates outlined under this rule, the processor shall immediately:
(1) Provide written notification in a manner prescribed by the division;
(2) Quarantine and separate the ingredient from all other viable ingredients, cannabis, and inventory;
(3) Preclude use of the ingredient in any cannabis product; and
(4) Maintain the ingredient in an unaltered state at the licensed premises pending further written direction by the division.
(5) The division may require the licensee to destroy the ingredient, in accordance with rule 1301:18-3-12 of the Administrative Code.
(I) Specific requirements for hemp-derived ingredients. Unless otherwise prohibited by this rule, a processor may utilize a hemp-derived ingredient in the manufacture of cannabis products provided it meets the following requirements:
(1) Prior to receipt of the ingredient at the licensed premises, the processor must ensure the following:
(a) The ingredient adheres to all other requirements outlined under this rule;
(b) The ingredient constitutes hemp, as defined by rule 1301:18-1-01 of the Administrative Code;
(c) The ingredient is contemporaneously and accurately recorded in the state inventory tracking system and categorized as hemp;
(d) The processor will receive the ingredient solely in final extracted form; and
(e) The ingredient contains an accompanying certificate of analysis evidencing compliance with all standards for state-required testing as outlined under rule 1301:18-4-13 of the Administrative Code from an accredited testing laboratory; or
(f) The processor:
(i) Within forty-eight hours of receipt at the licensed premises, submits the ingredient to a testing laboratory licensed pursuant to division 1301:18 of the Administrative Code;
(ii) Prior to utilizing in a cannabis product, ensures the ingredient complies with all standards for state-required testing as outlined under rule 1301:18-4-13 of the Administrative Code; and
(iii) Prior to utilizing in a cannabis product, ensures the associated certificate of analysis is uploaded in the state inventory tracking system.
(g) In the event a hemp-derived ingredient fails to meet the standards for state-required testing, the processor shall not remediate or re-test the ingredient and shall adhere to all requirements outlined under paragraph (H) of this rule.
Last updated October 5, 2026 at 7:46 AM
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